diff --git a/chapter2.qmd b/chapter2.qmd index 39203fb..bbe7bf7 100644 --- a/chapter2.qmd +++ b/chapter2.qmd @@ -211,14 +211,14 @@ tree-based learning algorithms and neural networks often performed best. @tbl-lab_ml displays the overview of their research. | **Author and Year** | **Objective and Machine Learning Task** | **Best Model** | **Major Themes** | -|:-----------------|:-----------------|:-----------------|:-----------------| +|:--------------------|:-----------------------------------------------------------------------------------------------------------------------|:----------------------|:---------------------------------------| | Azarkhish (2012) | Predict iron deficiency anemia and serum iron levels from CBC indices | Neural Network | Prediction | | Cao (2012) | Triage manual review for urinalysis samples | Tree-based | Automation | | Yang (2013) | Predict normal reference ranges of ESR for various laboratories based on geographic and other clinical features | Neural Network | Interpretation | | Lidbury (2015) | Predict liver function test results from other tests in the panel, highlighting redundancy in the liver function panel | Tree-based | Prediction, Utilization | | Demirci (2016) | Classify whether critical lab result is valid or invalid using other lab values and clinical information | Neural Network | Automation, Interpretation, Validation | | Luo (2016) | Predict ferritin from other tests in iron panel | Tree-based | Prediction, Utilization | -| Poole (2016) | Create personalized reference ranges that take into account patients\' diagnoses | Unsupervised learning | Interpretation | +| Poole (2016) | Create personalized reference ranges that take into account patients' diagnoses | Unsupervised learning | Interpretation | | Parr (2018) | Automate mapping of Veterans Affair laboratory data to LOINC codes | Tree-based | Information systems, Automation | | Wilkes (2018) | Classify urine steroid profiles as normal or abnormal, and further interpret into specific disease processes | Tree-based | Interpretation, Automation | | Fillmore (2019) | Automate mapping of Veterans Affair laboratory data to LOINC codes | Tree-based | Information systems, Automation | diff --git a/chapter5.qmd b/chapter5.qmd index c7528f1..78247c2 100644 --- a/chapter5.qmd +++ b/chapter5.qmd @@ -15,11 +15,12 @@ the algorithm had a false positive rate of 8% and a false negative rate of 20%. In the original data, 67% of the time, the result was non-diagnostic for Hyper-Thryodism. -1846 - Hypo - -423 - Hyper - -9170 - High TSH (hypo) +While TSH was expected to be the most important variable in building +random forest models, it was quite unexpected that the next three values +would be Hematology results. In the clinical laboratory, TSH and CBCs +are often run on different analyzers and often in completely different +departments. Finding this slight correlation could be valuable to +building further algorithms. ## Real World Applications @@ -49,6 +50,13 @@ informationally redundant testing [@luo2016]. However, since Free T4 and all other tests used in this study are performed on automated instruments, the cost savings to the lab and patient may be minimal. +As Rabbani et al. study showed, Machine Learning in the Clinical +Laboratory is an emerging field. However, few existing studies relate to +predicting laboratory values based on other results [-@rabbani2022]. The +few studies that do exist follow a similar premise. All are trying to +reduce redundant laboratory testing and thus lower the cost burden on +the patient. + ## Study Limitations Section overview - In progress